In this cross-over episode from Bio Eats World, Kristen Fortney, cofounder and CEO of BioAge, joins Vijay Pande, founding partner of a16z Bio + Health, and Olivia Webb, editorial lead, to discuss the biology of aging, how she started a company, and some fun things — like how long a hypothetical venture capitalist can expect to live.

At the end of 2022, our team at a16z asked dozens of partners across the firm to spotlight one big idea that startups in their fields could tackle in 2023. Emerging from this exercise came 40+ builder-worthy pursuits for the year, ranging from entertainment franchise games to precision delivery of medicine to small modular reactors, and of course loads of AI applications. In our 2-part series, we’ll be covering 12 of these big ideas with the partners that shared them. Here in part 2, we’ll cover Fintech, American Dynamism, and Bio & Health. Listen in as we chat with Anish Acharya, Angela Strange, Michelle Volz, Ryan McEntush, Vijay Pande, and Julie Yoo. And for the full list of 40+ ideas, check out the full article: https://a16z.com/2022/12/15/big-ideas-in-tech-2023/ Topics Covered: (0:59) GPT Unlocks Credit Counseling - Anish Acharya (9:53) Compliance as a Competitive Advantage - Angela Strange (23:31) Small Modular Reactors Advance the Nuclear Renaissance - Michelle Volz (33:48) Overhauling the Space Supply Chain - Ryan McEntush (44:40) The Biggest Company in the World - Vijay Pande (51:17) The Value-Based Care Stack - Julie Yoo

At the end of 2022, our team at a16z asked dozens of partners across the firm to spotlight one big idea that startups in their fields could tackle in 2023. Emerging from this exercise came 40+ builder-worthy pursuits for the year, ranging from entertainment franchise games to precision delivery of medicine to small modular reactors, and of course loads of AI applications. In our 2-part series, we’ll be covering 12 of these big ideas with the partners that shared them. Here in part 1, we’ll cover Consumer, Games, and Enterprise, with a little Fintech sprinkled in. Listen in as we chat with Connie Chan, Anne Lee Skates, Jack Soslow, Doug McCracken, Sarah Wang, and Sumeet Singh. And look out for part 2 dropping soon, covering Fintech, American Dynamism, and Bio & Health! And for the full list of 40+ ideas, check out the full article: https://a16z.com/2022/12/15/big-ideas-in-tech-2023/ Topics Covered: (1:30) Breakthroughs in Buying (Finally!) - Connie Chan (16:40) Unlocking the “Third Place” - Anne Lee Skates (30:14) Games as a Neverending Turing Test - Jack Soslow (46:09) The Metaverse Goes Fashion Forward - Doug McCracken (59:24) Generative AI Advances Beyond “Text to Image” to Complex Workflows - Sarah Wang (1:12:23) Embracing Large Language Models and Maintaining Trust - Sumeet Singh

In this special episode, we share never heard before footage from Steve Wozniak alongside his cofounder and best man, Alex Fielding. Listeners get an inside look into what drove Woz to building a computer, but also how Steve’s zest for life was applied beyond computers – from the rare opportunity to play Tetris on the side of a building or throw a concert across borders.

New year, new you! Right? Well, as much as we’d all like to believe that we embrace the new… the reality is that we often resist change. That’s why we’ve brought in someone who has studied how humans respond to and adapt to change – or sometimes how we fail to. That person is Jason Feifer – long-time editor in chief at Entrepreneur Magazine, host of two popular podcasts, and recent author of his book Build for Tomorrow. Today, Jason shares 6 specific frameworks around the very natural human responses to change, which he’s developed through interviewing and studying some of the most influential people in the world – past and present. We also play a fun game at the end, where Jason comments on current technologies encountering pushback, and assesses where they might fit into his framework.

In this episode, Marc Andreessen and Vijay Pande discuss expert AI and its role in healthcare, bio, and more.

with @robertiger @cdixon @smc90 A wide-ranging conversation with Bob Iger on the interplay between technology, content, and distribution; as well as Bob’s journey -- and that of various creators! -- especially as the industry evolved from TV and cable to the advent of the internet/ web 1.0 to 2.0 to briefly touching on web3 and other emerging technologies. As well as topics top of mind for all company and community builders: from build vs. buy and the innovator's dilemma, to managing creativity, decentralization, remote work, and much more.

We’ve had some incredible guests join us on the a16z podcast this year, ranging from moonshot entrepreneurs, to top creators, to some of the most forward thinking technologists – all of which are busy shaping the future right before our eyes… We have so much more in store for 2023 and cannot wait for you to see who we bring on as guests. But before we turn the page, we wanted to recap some of the most interesting, thought-provoking segments from our 2022 roster. Here are 8 of our favorite clips, covering topics from AI to space to the metaverse… and beyond.

It’s been a century since the 40-hour work week was adopted, and decades since wifi has appeared on the scene. Despite countless new technologies fundamentally changing how we can work, many work practices have remained the same. COVID sent a shock into that system and many are left debating what the future of work holds. So in this episode, we speak with Alex Bouaziz, Darren Murph, and Sondre Rasch about the many ways companies are now being forced to adapt. Will companies shift toward more asynchronous work? How will a distributed model shift the way we hire? How will companies attract top talent, and is remote the only benefit that matters? What workers and companies will come out on top of this sea change? And of course… is the office dead? We’ll address these questions and more.

In this episode, we tackle three carbon removal projects of varying scale, business models, and technical challenges. -Biomass pyrolysis via Charm Industrial -An electrochemical process via Travertine -Mineralization via 44.01 We cover these companies through the lens of their founders – Peter Reinhardt (CEO of Charm Industrial), Laura Lammers (CEO of Travertine), and Karan Khimji (COO of 44.01) – who share the fascinating stories of how they stumbled into this industry, how their processes work, whether they can economically scale, and ultimately why each of them is dedicating their time and energy to this field. This episode also closes out our carbon removal mini series, where we’ve seen a unique convergence of attention, capital, policy, and creativity being applied. With that combination, it's rare that humans don't surprise one another in progress.

If you’ve been following the news, you’ve probably heard of the recent FTX scandal. While there’s much still unknown, in this episode we get the unique opportunity to hear from Brian Armstrong – co-founder and CEO of Coinbase – about what’s top of mind for the crypto industry. That includes the impact of this current event on future regulation, how this crypto winter might be different from previous ones, founder psychology during downturns, the transparency that comes with being public, and much more. Brian is interviewed by a16z cofounder and general partner Ben Horowitz, who has the unique perspective of having invested in, built, and been on the board of numerous companies during the ups and downs, leading him to his well-known book The Hard Thing About Hard Things.

In part 1 of our carbon removal series, we talked to Nan Ransohoff — Head of Climate at Stripe — about what it might take to jumpstart the market of carbon removal solutions. But what happens when there is a true, thriving market of buyers and sellers? How will suppliers effectively reach the right buyers, and as more solutions become available, how will buyers effectively vet the options? In part 2, we address these questions and more, together with Brennan Spellacy, co-founder & CEO of Patch – a growing marketplace for carbon credits. We also cover many evolving market dynamics, like the potential differences between two sets of tons delivered, the opportunity and challenge of effectively educating buyers, the integration of software like Patch's API, verification solutions and their current limitations, how even the voluntary market is being held accountable for their carbon claims, and the role that Patch is playing to help develop this nascent industry. By the way, if you like this episode, be sure to look out for part 3 of our series where we get into the nitty gritty of 3 emerging carbon removal solutions — ranging from biomass pyrolysis to carbon mineralization.

What happens when there’s demand for a solution that doesn’t quite exist yet? Today, we bring on Nan Ransohoff to talk about this exact problem as it relates to carbon removal, and how Frontier — the initiative out of Stripe that she is leading – is using a nearly $1B advance market commitment to try to jumpstart this market. If you don’t know what that means, don’t worry – we’ve got you covered. Throughout the episode, we discuss the multivariate carbon equation and why emission reductions are not enough, the difference between offsets and permanent removal, who’s paying for tons today, what solutions already exist and how Frontier is vetting them, moving down the cost curve, where policy fits in, and ultimately what success might look like in this nascent industry. This is part 1 of our 3-part series on carbon removal. Look out next week for part 2 and part 3, where we dive into a growing marketplace for carbon and showcase several carbon removal solutions.

In today’s episode, we have a special treat. Flexport’s co-CEO and Founder, Ryan Petersen, chats with a16z Growth Editor Das Rush. They start with the question of why Ryan has chosen – of all the problem spaces to work on – improving the resiliency of the supply chain. They cover just how complex the supply chain is in the era of ecommerce, evolving customer expectations, and ultimately how we can rearchitect our supply chain to meet them. Given the holiday shopping coming up, you won’t want to miss this.

When Neal Stephenson coined “the metaverse” three decades ago, his book Snow Crash was found on the shelves of “science fiction”. While the book remains in that category, many of its concepts are now found in reality… Fast forward to 2022, where numerous companies are now building toward their version of the metaverse, including Neal himself – working on Lamina1 – a blockchain company oriented toward creators. While the present metaverses don’t perfectly mimic that from Stephenson’s early imagination, we get the unique opportunity to discuss the various design decisions that he’s making, but also the intersection between the metaverse and gaming, the involvement that AR/VR might play, the evolving role of IP, how artificial intelligence fits in, what he’s building and why, and where he gets all of his ideas from.

Today, we have an episode with Chris Power, the founder and CEO of Hadrian. Hadrian is a company trying to build the most efficient factories on the planet. In this conversation, we’ll introduce the audience to advanced manufacturing, and expose them to the reality that it’s a remnant of the first space race. We also cover the challenge of manufacturing, the importance of visibility in complex systems, the killer app for space, how simplifying the world of atoms can be done through bits – and ultimately, what kind of experimentation that may unlock.

In this episode, we’ll explore the concept of The Network State with Balaji Srinivasan. As the world becomes more digital, it also becomes more distributed. This is obvious on the individual level – how you order goods, the way you chat with friends, and the news you consume… all from a handheld computer. It’s also becoming more obvious at the company level. The pandemic shook the world into remote work and many companies have decided that maybe work can be done in ways they never imagined. But what about the state – whatever that means? Could the network rival the state? In this episode we’ll explore what a nation state even is and how it may be challenged by a new Leviathan: the network. We also cover the difference between a nation and a state, how constants become variables, the cloud continent, digital power, your identity stack, calibrating risk, polycentric law, cloud regulations, building fast with atoms, founding vs inheriting, the powerful vs the powerless, and just about everything in between.

Many people consider space to be the next frontier and equally an infinite horizon to explore. But the reality is that not all “space” is the same and there are strategic zones that don’t only matter up there – but down here on Earth. Lower Earth Orbit (LEO) is one of those regions – a zone filled with satellites that support life on Earth, from agriculture to climate to navigation to defense. Unfortunately, these live satellites are not alone in our space highways. LEO is getting increasingly clogged with space debris; we’re polluting our skies just like we’re polluting our land. In this episode, we have the pleasure of speaking with all three cofounders of Privateer – Steve Wozniak, Alex Fielding, and Dr. Moriba Jah, as they explore just how much junk is up there, how this challenge is expected to progress with time due to lower launch costs, and ultimately, what infrastructure is missing in this fragile ecosystem – from tracking to global treaties to a sharing economy of satellites. By the end of the episode, listeners should be more equipped to understand how our infrastructure in space vastly impacts life on Earth, how the preservation of this ecosystem is crucial, and how Privateer is providing the map to better understand and fix the issue.

With much coverage of technology lined with pessimism, the a16z Podcast returns to highlight the bright side of technology, alongside the founders building it. But before featuring the solutions in progress, we wanted to explore why building the future is still so important. And who better to traverse this ground than a16z’s own cofounder Marc Andreessen, who has built and invested in the future time and time again, especially when it wasn't the obvious thing to do. Together with Marc, this episode explores technology through the lens of history – including the three stages of human psychology as we encounter new technologies, how that process often manifests in regulation, when to change your mind, the Cambrian explosion of opportunity coming from distributed work, the importance of founder-led companies, and perhaps most importantly, we examine why there's still much reason for optimism.

Generative AI tools like DALL-E, Midjourney, and Stable Diffusion have taken the world by storm in recent months, wowing the masses with their uncanny ability to produce images via text prompts. In this interview, we’ll chat with Karen Cheng about how she’s leveraged these tools among others, with a focus on how this new paradigm is reshaping the creator landscape. You’ll get to hear the behind the scenes of many of her viral works, including a video of her becoming a lawnmower, her AI-generated Cosmo magazine cover, her DALL-E fashion show, her transforming iconic art into 3D museums to explore, and much, much more. By the end of this episode, listeners should have a better understanding of the new tools at their fingertips (literally!), how AI can indeed enhance the creative process, and the second-order effects of these innovations, like how creators are paid. Since we’re just at the beginning of the AI era, this is just the beginning of our coverage as well.