with @DrIvorHorn, @jeffkaditz, @julesyoo, @omnivorousread Primary care was meant to be the front door to the healthcare system, but in some ways never set up for success to begin with. We need a new operating system for primary care—one with a different, deeper understanding of the patient, the context of their world around them, and the processes we have in place to figure out who sees a doctor and when, in order to use the healthcare system most efficiently. In this episode of the a16z Podcast, we talk about what the primary care of the future should actually look like and new ways we can understand what patients and doctors truly need, when. Joining us for the conversation are General Partner Julie Yoo, physician entrepreneur Ivor Horn, a primary care pediatrician for more than 20 years, and Jeff Kaditz, CEO and founder of Q.bio, a platform that identifies and monitors each individual’s biggest health risks.

with @mmasnick and @smc90 What does (and doesn’t) this section of the Communications Decency Act really say; common myths and misconceptions; and much more on this recent episode of our show 16 Minutes, where we cover headlines and tech trends -- offering analysis, frameworks, explainers, and more: a16z.com/16minutes

with terrybrown @shakasenghor @bhorowitz Given recent events around George Floyd and far beyond, this special episode of the a16z Podcast features Shaka Senghor, a leading advocate for criminal justice reform, and Terry Brown, a former police officer in East Palo Alto -- who, incidentally, both grew up in Detroit but ended up on different sides of the law -- in conversation with a16z co-founder Ben Horowitz. The conversation goes deep and on the ground...

It's easier to move upmarket than down. We look at why this gives SaaS startups the advantage against incumbents and how to price for the move.

Today’s episode is about a practical application of crypto — namely, the way it can “tokenize” fandom. More broadly, it’s about fan engagement, and the increasingly blurred lines between sports, culture and tech.  We talked to NBA player Spencer Dinwiddie, of the Brooklyn Nets. Spencer created a new platform on the crypto blockchain Ethereum that gives fans the opportunity to invest directly in his revenue-generating potential, through debt securities.  Joining this conversation are a16z managing partner and tech investor Jeff Jordan, who has long followed the evolving relationship between sports and tech. Also joining is Jesse Walden, a former a16z crypto partner and co-founder of Mediachain. He’s also a former music promoter and manager whose focus was on helping artists stay independent.   We discuss the evolution of models for fan engagement; how social media has changed the game; and where technologies like cryptonetworks and blockchains come in. Stay Updated: Find a16z on X Find a16z on LinkedIn Listen to the a16z Show on Spotify Listen to the a16z Show on Apple Podcasts Follow our host: https://twitter.com/eriktorenberg   Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures. Hosted by Simplecast, an AdsWizz company. See https://pcm.adswizz.com for information about our collection and use of personal data for advertising.

with @PascaStanford, @VijayPande, and @omnivorousread Our understanding of the human brain and its disorders has always been limited by our lack of access to living, human, developing brain tissue. For the first time, that's changing. In this episode, Sergiu Pasca, Professor of Behavioral Science at Stanford, talks with a16'z General Partner Vijay Pande and Hanne Tidnam about the wild new tech that's pioneering a whole new approach to understanding the brain: brain organoids. This conversation covers what these organoids can and can’t do; what they’re good for understanding and where that understanding becomes limited; why calling these “brains in a dish” or “mini-brains” isn’t the right terminology at all; and finally, how far can this new tool and model be taken now and in the future, leading us closer towards understanding psychology itself on a molecular level.

with @nachristakis @jorgecondebio Going from rapid warning to early detection through social network sensors can make all the difference when it comes to contagion/ the spread of disease and pandemics. Can we get public health bio surveillance without sacrificing privacy and agency?

with @nwquah @conniechan and @smc90 This (rerun) podcast is a podcast about podcasting: But it's really all about audio...

In normal times, every company operates against some hypothetical growth model—a data-driven framework that describes how your product grows and how you acquire new users. These, of course, are not normal times. In the fallout from the pandemic, most founders and CEOs are in the process of completely revamping their growth models from the bottom up amid new and unpredictable consumer behavior. This episode explores how to think about growth in turbulent times, according to two growth experts: a16z general partner Andrew Chen, who previously led the growth team at Uber, and Brian Balfour, formerly the VP of Growth at HubSpot, now the founder and CEO of Reforge, a masterclass in growth strategies.

with @vijaypande, @andy23tran, and @lr_bio a16z Journal Club covers a new approach for preventing coronavirus and influenza infection using the genome editing platform CRISPR-Cas.

John Riccitiello, CEO of the game software development company Unity Technologies, discusses the rise of esports and streaming, the potential of cloud gaming, and far-reaching applications for game technology.

with @jaybrander, @JorgeCondeBio, @vijaypande, @omnivorousread A deep dive into the world of drug development—specifically "undruggable drugs": a category of protein, protein family or even piece of RNA that’s so difficult to target that many researchers don’t even want to touch it—with Jay Bradner, President of the Novartis Institute for BioMedical Research.

This episode—which originally took place as a live event—is a conversation between Seattle Seahawks linebacker Bobby Wagner and a16z Cultural Leadership Fund partner Chris Lyons.

As the responsibility of CSOs has expanded, the role has moved from technical IT to the boardroom. How do the best CSOs prepare for and respond to a crisis, from redteaming to comms? What responsibility should cloud & SaaS vendors, not to mention the government, have in security and data breaches?

with @vijaypande @andy23tran @heyjudka @lr_bio a16z Journal Club covers recent advances from the scientific literature; this inaugural episode for bio covers 2 two different topics: (1) identifying new antibiotics through a novel machine-learning based approach; and (2) characterizing the novel coronavirus causing the COVID-19 pandemic

Announcing a16z Journal Club, a new show where we curate and discuss recent research papers with a16z experts and others. The first episode is of bio journal club, which focuses on why specific scientific advances matter from our perspective at the intersection of biology & technology.

Today’s episode is one of our intimate hallway-style conversations — or as intimate as remote work allows anyway. It’s all about the history and future of protocol development. a16z crypto partner Ali Yahya, formerly Distributed Systems & Machine Learning researcher at Stanford & Google Brain, wrote a tweetstorm earlier this year about the “Narrow Waist of Blockchain Computing” (we link to in the show notes). Ali observed that the Internet Protocol, which emerged out of research labs and government funding decades ago, has taken the world from zero devices to more than 15 billion connected devices today. What was it about the Internet Protocol that allowed building so many applications on top? Helping us answer this question is a16z general partner in enterprise Martin Casado, who pioneered software-defined networking. He co-founded Nicira, which was acquired by VMware; and then he led their Networking and Security Business Unit, which he scaled to a hugely successful business, so he knows a thing or two about this topic. The two debate the tension between bottom-up design and top-down architected approaches to internet applications, including the role of standards bodies. More broadly, their discussion is about how innovation plays out in practice, and they end by sharing advice for entrepreneurs today. But they begin with a quick history and description of the “Narrow Waist,” and the conditions that create it:

@pmarca reads out loud IT'S TIME TO BUILD

an announcement about a new, occasional series of posts from us, read out loud here

with @ljin18 @samyamiam @laurenmurrow The Passion Economy -- where online platforms enable people to make a living off their unique interests and skills -- is a trend that's become increasingly relevant as the demand for virtual work grows.