with @andrewchen @jeff_jordan @smc90 What happens as marketplaces and other platforms evolve over time, and different kinds of users also join over time? After user acquisition, it's all about user retention and engagement. So what are the key metrics?

Susan Rice is interviewed by a16z General Partner Kathryn Haun. Rice, the former National Security Advisor and U.S. Ambassador to the U.N., learned early in life the importance of toughness in the face of adversity. In this discussion, she shares many more lessons from her personal life and career, including how to stay calm during crises, not letting others define you, and work-life balance.

CAR T therapy, the groundbreaking new medicines that uses engineered T-cells to attack cancer, has been so effective in childhood leukemias that we believe it may actually be a potential cure. But this isn't just one new medicine, it's an entirely new therapeutic tool—and a total paradigm shift from most traditional medicines we've seen before.

with @francescagino and @omnivorousread In this episode of the a16z Podcast, Harvard Business School Professor Francesca Gino, a social scientist who studies organizations, breaks down what makes rebels different in how they tend to see and do things—whether that’s cooking, flying planes, or holding board meetings—and what we can all learn from “rebel talent” to make our organizations more productive and innovative.

with @heyjudka @smc90 This episode of 16 Minutes on the news from a16z (cross-posted here as well) covers what we know and what we don't know about the recent coronavirus outbreak 2019-nCoV. Topics covered include the what, when, how -- and where genomics comes in.

The idea of "1000 true fans" argued that to be a successful creator, you don’t need millions of customers or clients, as long as you also have a direct relationship with those fans. But how is media changing today as a result, and what nuances do people often miss about the concept? And why are we apparently surrendering our attention (whether to TV, books, or whatever) for only $3 an hour?!

with @cjgbest @robertcottrell @andrewchen @smc90 A new ecosystem is forming around the direct relationship between consumers, content creators, and the tools and business models to facilitate all that. We're not just seeing this phenomenon in newsletters and podcasting, but also in people setting up e-commerce shops, video streaming, and more. Are the stars and the incentives finally aligned?

Chris Dixon, a16z General Partner, is interviewed by Jonah Peretti, founder and CEO of Buzzfeed. They discuss all things internet, including how innovation comes about, the ways disparate trends collide, and more.

AI can do a lot of specific tasks as well as, or even better than, humans can — for example, it can more accurately classify images, more efficiently process mail, and more logically manipulate a Go board. While we have made a lot of advances in task-specific AI, how far are we from artificial general intelligence (AGI), that is AI that matches general human intelligence and capabilities? In this podcast, a16z operating partner Frank Chen interviews Stuart Russell, Founder of the Center for Human-Compatible Artificial Intelligence (CHAI) at UC Berkeley. They outline the conceptual breakthroughs, like natural language understanding, still required for AGI. But more importantly, they explain how and why we should design AI systems to ensure that we can control AI, and eventually AGI, when it’s smarter than we are. The conversation starts by explaining what Hollywood's Skynet gets wrong and ends with why AI is better as "the perfect Butler, than the genie in the lamp."

The federal agency known as the FDA, or the Food and Drug Administration, was born over 100 years ago—at the turn of the industrial revolution, in a time of enormous upheaval and change, and rapidly emerging technology. The same could be said to be just as true today. This wide-ranging conversation between Principal Commissioner of the FDA Amy Abernethy and Vijay Pande, GP on the Bio Fund at a16z, discusses how the agency is evolving to keep pace with the scientific breakthroughs like CRISPR and AI, while staying true to its core mission of assessing safety and effectiveness for consumers in the world of food and medicine.

with @vasnarasimhan @jorgecondebio @vijaypande @smc90 How does the world’s largest producer of medicines in terms of volume balance the science and  the business of innovation, from R&D to go to market to talent and more?

with @jorgecondebio and @smc90 A look-back and look-forward on the topic of personal genomics, given recent and past retrospective and prospective pieces in the media on the topics of DNA sequencing, personalized medicine, criminal investigations, genetic privacy and large datasets, multiomics, and more.

Kevin Kelly interviews Marc Andreessen at our most recent innovation Summit; they discuss the evolution of technology, key trends, and why they're the most optimistic people in the room.

with @mikeleiter @katie_haun What does the Committee on Foreign Investment in the U.S. (CFIUS) and updates to the Foreign Investment Risk Review Modernization Act (FIRRMA) mean for founders taking investments from or doing joint ventures with foreign entities or just doing business globally in general? What does and doesn't CFIUS cover, and how might one structure partnerships strategically as a result?

A bold proposal: You go to college for free, then pay back the school after graduation—but only if you get a job in your field of study and make a high enough salary to afford it. It's called an income share agreement, and Austen Allred, the CEO and cofounder of Lambda School, thinks it's the future of education.

with @shondarhimes @pmarca The creator of hit shows like Grey's Anatomy, Scandal, and others, writer and executive producer Shonda Rhimes shares lessons she's learned about pitching ideas, storytelling, leadership, and scaling a business across mediums.

with @pmarca and @mjr2 In this special guest hosted episode -- cross-posted from the new show Starting Greatness (featuring interviews with startup builders before they were successful, hosted by Mike Maples jr) -- Marc Andreessen shares some rare, behind-the-scenes details of his story from 0 to 1... from the University of Illinois and Mosaic to Netscape.

with @stacey_cunning barrymccarthy @smc90 Another route to the public markets is the direct listing, recently reinvented for tech companies (with Spotify and Slack so far). This episode of the a16z Podcast brings together two experts from the frontlines -- the architect of the direct listings in their current form, the CFO of Spotify; and president of the NYSE, where they were listed -- in conversation with Sonal Chokshi to share more about the what, the how, and the why from an insider perspective. What does it, did it take?

with @bhorowitz @smc90 How do you build, set, shape, fix, change, culture? Sharing practical advice while drawing on examples of culture as code from a thousand years ago to today, as shared in his new book What You Do Is Who You Are, Horowitz shares the power of song and story. Including even violent, "shocking" ones that reset cultures, because they make you ask, WHY?!

The world's largest shopping days (Black Friday, Singles Day in China, Prime Day online, and so on) means shipping lots and lots of boxes, via big-box retailers and container ships -- but that's not the only reason we're re-running this episode of the a16z Podcast from 2017 with The Box author Marc Levinson. It's because we love logistics and infrastructure, and is really about how global innovation happens... through all sorts of invisible details.