🇺🇸 United States Episodes

Life-saving therapeutics continue to grow more costly to discover. At the same time, recent advances in using machine learning for the life sciences and medicine are extraordinary. Are we on the verge of a paradigm shift in biotech? This week on the podcast, a pioneer in AI, Daphne Koller, joins Sarah Guo and Elad Gil on the podcast to help us explore that question. Daphne is the CEO and founder of Insitro — a company that applies machine learning to pharma discovery and development, specifically by leveraging “induced pluripotent stem cells.” We explain Insitro’s approach, why they’re focused on generating their own data, why you can’t cure schizophrenia in mice, and how to design a culture that supports both research and engineering. Daphne was previously a computer science professor at Stanford, and co-founder and co-CEO of edutech company Coursera. Show Links:  Insitro - About  Video: AWS re:Invent 2019 – Daphne Koller of insitro Talks About Using AWS to Transform Drug Development  Sign up for new podcasts every week. Email feedback to [email protected] Follow us on Twitter: @NoPriorsPod | @Saranormous | @EladGil | @DaphneKoller Show Notes:  [1:49] - How Daphne combined her biology and tech interests and ran a bifurcated lab at Stanford [4:34] - Why Daphne resigned an endowed chair at Stanford to build Coursera  [14:14] - How insitro approaches target identification problems and training data  [18:33] - What are pluripotent stem cells and how insitro identifies individual neurons  [24:08 ] - How insitro operates as an engine for drug discovery and partners to create the drugs themselves [26:48] - Role of regulations, clinical trials and disease progression in drug delivery  [33:19] - Building a team and workplace culture that can bridge both bio and computer sciences  [39:50] - What Daphne is paying attention to in the so-called golden age of machine learning   [43:12] - Advice for leading a startup in edtech and healthtech

Hard challenges demand that we embrace tension. Former CEO of IBM Ginni Rometty argues that, right now, business has a responsibility to deploy what her new book calls Good Power — from putting skills first in hiring, as a way to close systemic opportunity gaps, to thoughtfully erecting guardrails around new technology. As an early pioneer in the AI space with IBM’s Watson, Ginni acknowledges the risk that disruptive technology can have on society. She offers her insider perspective on balancing what she calls “the teeter-totter” of marketplace demands with positive long-term impact.Read a transcript of this episode: https://mastersofscale.com/Subscribe to the Masters of Scale weekly newsletter: https://mastersofscale.com/subscribeSee Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Mary Harrington is a contributing editor at UnHerd and an author. Women have been subject to a lot of changes over the past 200 years. Liberated first from the land, then from the house, then from the womb, and finally even from their own nature. But has it actually helped? Has modern feminism been for the best or has it made women's lives more confusing than ever? Expect to learn why feminism might not have delivered on the promises it made to the world, why there is a war on relationships between the sexes, Mary's guess on why there are so few families getting together, how women's liberation has only worked for a small number of women at the expense of many others, why abortion and birth control actually led to more single parent households and much more... Sponsors: Get $100 off plus an extra 15% discount on Qualia Mind at https://neurohacker.com/modernwisdom (use code MW15) Get 83% discount & 3 months free from Surfshark VPN at https://surfshark.deals/MODERNWISDOM (use code MODERNWISDOM) Get 20% discount on House Of Macadamias’ nuts at https://houseofmacadamias.com/modernwisdom (use code MW20) Extra Stuff: Buy Feminism Against Progress - https://amzn.to/3YUNkfY  Subscribe to Mary's Substack - https://reactionaryfeminist.substack.com/  Get my free Reading List of 100 books to read before you die → https://chriswillx.com/books/ To support me on Patreon (thank you): https://www.patreon.com/modernwisdom - Get in touch. Instagram: https://www.instagram.com/chriswillx Twitter: https://www.twitter.com/chriswillx YouTube: https://www.youtube.com/modernwisdompodcast Email: https://chriswillx.com/contact/  Learn more about your ad choices. Visit megaphone.fm/adchoices

If you are a congressperson or a senator and you have an idea for a new piece of legislation, at some point someone will have to tell you how much it costs. But, how do you put a price on something that doesn't exist yet?Since 1974, that has been the job of the Congressional Budget Office, or the CBO. The agency plays a critical role in the legislative process: bills can live and die by the cost estimates the CBO produces.The economists and budget experts at the CBO, though, are far more than just a bunch of number crunchers. Sometimes, when the job is really at its most fun, they are basically tasked with predicting the future. The CBO has to estimate the cost of unreleased products and imagine markets that don't yet exist — and someone always hates the number they come up with.On today's episode, we go inside the CBO to tell the twisting tale behind the pricing of a single piece of massive legislation — when the U.S. decided to finally cover prescription drug insurance for seniors. At the time, some of the drugs the CBO was trying to price didn't even exist yet. But the CBO still had to tell Congress how much the bill would cost — even though the agency knew better than anyone that its math would almost definitely be wrong.We want to hear your thoughts on the show! We have a short, anonymous survey we'd love for you to fill out: n.pr/pmsurvey Help support Planet Money and get bonus episodes by subscribing to Planet Money+ in Apple Podcasts or at plus.npr.org/planetmoney.Learn more about sponsor message choices: podcastchoices.com/adchoicesNPR Privacy Policy

Tony Hinchcliffe is a stand-up comedian, writer, and actor. He's also the co-host, along with Brian Redban, of the podcast and live-streaming YouTube show "Kill Tony."  Brian Redban is a comedian, producer, and founder of the Deathsquad podcast network. Learn more about your ad choices. Visit podcastchoices.com/adchoices

As a proud and passionate restaurant owner, Vincent Yeow Lim takes after his father and grandfather in the family tradition of Chinese cooking. Lim makes a delicious case to elevate the reputation of Chinese food, sharing why the comforting flavors behind iconic dishes -- like a hearty helping of perfectly made fried rice -- come from a long line of love, nostalgia and mastery that deserves to be recognized.Learn more about our flagship conference happening this April at attend.ted.com/podcast Hosted on Acast. See acast.com/privacy for more information.

Should AI belong in the courtroom? Joshua Browder ventured to run an experiment where a robot lawyer would defend a court case. Looking to up the ante, he even offered $1m for a Supreme Court hearing! His experiment was met with a threat of 6 months jail time. Listen in for the full story.

Original Air Date: November 18, 2018 At the Hearst Tower in New York City, Oprah Winfrey and Michelle Obama sit down for a conversation about Mrs. Obama’s NYTimes number one best-selling memoir “Becoming.” The two speak in front of an audience that includes a group of local, female high school students. The former first lady, mother, wife, attorney and author discusses the life experiences that have shaped her. She reminisces about her humble childhood on the South Side of Chicago with her family, which she describes as “four corners of a square:” her mother, Marian, her late father, Fraser, and her brother, Craig. Mrs. Obama explains how her parents invested everything they had into her and her brother’s futures. She discusses her years as an attorney and executive in Chicago and how she worked to balance the demands of her career and raising two daughters. Mrs. Obama candidly discusses some of the challenges she and Barack Obama faced during the early years of their marriage, including a stint in counseling. She also opens up about her years in the White House and the pressure of being the “first Black family” to live there.

Original Air Date: November 14, 2018 At the Hearst Tower in New York City, Oprah Winfrey and Michelle Obama sit down for a conversation about Mrs. Obama’s NYTimes number one best-selling memoir “Becoming.” The two speak in front of an audience that includes a group of local, female high school students. The former first lady, mother, wife, attorney and author discusses the life experiences that have shaped her. She reminisces about her humble childhood on the South Side of Chicago with her family, which she describes as “four corners of a square:” her mother, Marian, her late father, Fraser, and her brother, Craig. Mrs. Obama explains how her parents invested everything they had into her and her brother’s futures. She discusses her years as an attorney and executive in Chicago and how she worked to balance the demands of her career and raising two daughters. Mrs. Obama candidly discusses some of the challenges she and Barack Obama faced during the early years of their marriage, including a stint in counseling. She also opens up about her years in the White House and the pressure of being the “first Black family” to live there.

Chris Distefano is a stand-up comedian, on-air personality, host of the "Chrissy Chaos" podcast, and co-host of "Hey Babe!" podcast with Sal Vulcano. His new comedy album, "Chrissy New York Comedy Club", is available now. www.chrisdcomedy.com Learn more about your ad choices. Visit podcastchoices.com/adchoices

Scientist Saad Bhamla is on a mission to answer a question most people don't think to ask: How do insects pee? Taking inspiration from the incredible "butt flickers" of the glassy-winged sharpshooter, Bhamla presents a fascinating study of the physics behind how bugs take care of business and invites us to be more curious about the seemingly mundane.Learn more about our flagship conference happening this April at attend.ted.com/podcast Hosted on Acast. See acast.com/privacy for more information.

Better practices for building inclusive cultures and communication.

Online influencers are an increasingly important way for companies to find new customers and drive sales. Whether you're a marketer who wants to more effectively use social media or a consumer targeted by influencer content - in good ways and bad - you'll benefit from better understanding how the industry works. Emily Hund, researcher at the University of Pennsylvania, explains that it was born from not only increased connectivity but also Great Recession job cuts which forced people in creative fields to innovate. She argues that these are entrepreneurs who now have an impact on many different sectors of the economy and offers advice for both them and the brands wanting to develop better influencer marketing strategies. Hund is the author of the book The Influencer Industry: The Quest for Authenticity on Social Media.

Episode 424: Shaan Puri (@ShaanVP) and Sam Parr (@TheSamParr) talk about the greatest business of all time, what psy-ops can do, the work smarter not harder hack with Parallel Live Simulator, and much more. Want to see more MFM? Subscribe to the MFM YouTube channel here. ----- Links: * SEC Filing for LDS Church * Team Jorge Wiki * Parallel - Live Simulator * James Currier Twitter * NFX * Do you love MFM and want to see Sam and Shaan's smiling faces? Subscribe to our Youtube channel. * Want more insights like MFM? Check out Shaan's newsletter. ------ Show Notes: (00:35) - The greatest business ever (17:40) - Psy-ops as a service (35:45) - The work smarter not harder hack (39:50) - Shaan meeting with James Currier (50:50) - The four things you need to know for a great business partnership ----- Past guests on My First Million include Rob Dyrdek, Hasan Minhaj, Balaji Srinivasan, Jake Paul, Dr. Andrew Huberman, Gary Vee, Lance Armstrong, Sophia Amoruso, Ariel Helwani, Ramit Sethi, Stanley Druckenmiller, Peter Diamandis, Dharmesh Shah, Brian Halligan, Marc Lore, Jason Calacanis, Andrew Wilkinson, Julian Shapiro, Kat Cole, Codie Sanchez, Nader Al-Naji, Steph Smith, Trung Phan, Nick Huber, Anthony Pompliano, Ben Askren, Ramon Van Meer, Brianne Kimmel, Andrew Gazdecki, Scott Belsky, Moiz Ali, Dan Held, Elaine Zelby, Michael Saylor, Ryan Begelman, Jack Butcher, Reed Duchscher, Tai Lopez, Harley Finkelstein, Alexa von Tobel, Noah Kagan, Nick Bare, Greg Isenberg, James Altucher, Randy Hetrick and more. ----- Additional episodes you might enjoy: • #224 Rob Dyrdek - How Tracking Every Second of His Life Took Rob Drydek from 0 to $405M in Exits • #209 Gary Vaynerchuk - Why NFTS Are the Future • #178 Balaji Srinivasan - Balaji on How to Fix the Media, Cloud Cities & Crypto * #169 - How One Man Started 5, Billion Dollar Companies, Dan Gilbert's Empire, & Talking With Warren Buffett • ​​​​#218 - Why You Should Take a Think Week Like Bill Gates • Dave Portnoy vs The World, Extreme Body Monitoring, The Future of Apparel Retail, "How Much is Anthony Pompliano Worth?", and More • How Mr Beast Got 100M Views in Less Than 4 Days, The $25M Chrome Extension, and More

What drove the meteoric rise of David Droga’s trailblazing agency Droga5? A series of daring, unexpected leaps — tactics he’s now applying at mega-scale as head of Accenture Song. Conventional wisdom tells you to ‘climb the ladder’ of success linearly — as an individual or a company. But David’s unexpected moves — leaning into creative partnerships and controversial programs — accelerated his path to scale. David tells us: “I’m more scared of repetition than I am of failure.”Read a transcript of this episode: https://mastersofscale.com/swing-on-the-jungle-gym-david-droga/Subscribe to the Masters of Scale weekly newsletter: https://mastersofscale.com/subscribeSee Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

My guest this week is Doug Leone. Doug led one of the world’s most successful venture firms, Sequoia, for over 25 years after he was given responsibility for the firm by its founder, Don Valentine, in 1996. Alongside Mike Moritz, the pair managed its expansion from a single $150m early-stage fund into an $85 billion global powerhouse. It was a privilege to sit down with Doug and learn from him. We talk about his tough start at Sequoia, get into the technicalities of great go-to-market motions, and survey his advice for other investors in the industry. A key theme that will stick with me from this conversation is Doug’s insistence on keeping things simple and clear. Please enjoy my great conversation with Doug Leone.   For the full show notes, transcript, and links to mentioned content, check out the episode page here.   -----   This episode is brought to you by Tegus, the modern research platform for leading investors. Whether it’s quantitative analysis, company disclosures, management presentations, earnings calls - Tegus has tools for every step of your investment research. They even have over 4000 fully driveable financial models. Tegus’ maniacal focus on quality, as well as its depth, breadth and recency of content makes it the one-stop, end-to-end research platform for investors. Move faster, gather deep research to build conviction and surface high-quality, alpha-driving insights to find your differentiated edge with Tegus. As a listener, you can take the Tegus platform for a free test drive by visiting tegus.co/patrick.   -----   Invest Like the Best is a property of Colossus, LLC. For more episodes of Invest Like the Best, visit joincolossus.com/episodes.    Stay up to date on all our podcasts by signing up to Colossus Weekly, our quick dive every Sunday highlighting the top business and investing concepts from our podcasts and the best of what we read that week. Sign up here.   Follow us on Twitter: @patrick_oshag | @JoinColossus   Show Notes [00:03:21] - [First question] - What Don Valentine’s heart was like [00:06:30] - The most productive and unproductive parts of Don’s toughness  [00:09:01] - Being the opposite of insufferable and how it was different when he was younger [00:10:55] - Why it’s so important to understand someone’s core motivations [00:14:18] - Questions or topics he returns to when getting to know people  [00:15:31] - How much time he believes it can take to really get to know someone   [00:20:37] - What venture looks like to him today relative to his prior career [00:23:51] - His style of approaching emerging technology markets like AI as an investor   [00:26:37] - Whether or not he’d go into venture today if he was in his late 20s  [00:28:30] - Commonalities between the very best at going to market effectively  [00:31:11] - The key components of great product positioning   [00:32:10] - Helping companies circumnavigate mediocre positioning  [00:33:25] - Generating demand and leads and doing it well  [00:37:15] - How interacting with companies early on has changed over the ears [00:46:14] - Sussing out the killer gene in somebody  [00:47:25] - What high school was like for him when he first came to the US  [00:49:04] - How successful people can instill the lessons learned from hardship into their children  [00:50:45] - The most common failure modes he’s seen for investors  [00:55:21] - The early 2000s clawback at Sequoia and what navigating that period was like  [00:59:06] - What he’s learned about picking the right LPs and partnering with them [01:00:40] - The most interesting question an LP has ever asked him  [01:02:18] - Making sure that performance is on everyone’s minds all the time  [01:04:04] - What the components of a fantastic investment memo are [01:05:00] - Which dinner companions he’d pick to educate a newly successful founder [01:05:29] - What first popped out at him as black magic when he started investing [01:07:59] - The kindest thing anyone has ever done for him

We negotiate all the time at work -- for raises, promotions, time off -- and we usually go into it like it's a battle. But it's not about dominating, says organizational psychologist Ruchi Sinha. It's about crafting a relationship, understanding your needs and the other person's. Her three key steps will help you master this essential skill.Learn more about our flagship conference happening this April at attend.ted.com/podcast Hosted on Acast. See acast.com/privacy for more information.

In this episode, my guest is Oded Rechavi, Ph.D., professor of neurobiology at Tel Aviv University and expert in how genes are inherited, how experiences shape genes and remarkably, how some memories of experiences can be passed via genes to offspring. We discuss his research challenging long-held tenets of genetic inheritance and the relevance of those findings to understanding key biological and psychological processes including metabolism, stress and trauma. He describes the history of the scientific exploration of the “heritability of acquired traits” and how epigenetics and RNA biology can account for some of the passage of certain experience-based memories. He discusses the importance of model organisms in scientific research and describes his work on how stressors and memories can be passed through small RNA molecules to multiple generations of offspring in ways that meaningfully affect their behavior. Nature vs. nurture is a commonly debated theme; Dr. Rechavi’s work represents a fundamental shift in our understanding of that debate, as well as genetic inheritance, brain function and evolution. For the full show notes, visit hubermanlab.com. Thank you to our sponsors AG1: https://athleticgreens.com/huberman LMNT: https://drinklmnt.com/hubermanlab Waking Up: https://wakingup.com/huberman Momentous: https://livemomentous.com/huberman Timestamps (00:00:00) Dr. Oded Rechavi (00:02:25) Sponsor: LMNT (00:06:04) DNA, RNA, Protein; Somatic vs. Germ Cells (00:14:36) Lamarckian Evolution, Inheritance of Acquired Traits (00:22:54) Paul Kammerer & Toad Morphology (00:25:16) Sponsor: AG1 (00:30:06) James McConnell & Memory Transfer (00:37:31) Weismann Barrier; Epigenetics  (00:45:13) Epigenetic Reprogramming; Imprinted Genes  (00:50:43) Nature vs. Nurture; Epigenetics & Offspring (00:59:06) Generational Epigenetic Inheritance  (01:10:20) Model Organisms, C. elegans (01:21:50) C. elegans & Inheritance of Acquired Traits, Small RNAs (01:26:02) RNA Interference, C. elegans & Virus Immunity (01:34:13) RNA Amplification, Multi-Generational Effects (01:38:41) Response Duration & Environment (01:47:50) Generational Memory Transmission, RNA (01:59:36) Germ Cells & Behavior; Body Cues (02:04:48) Transmission of Sexual Choice (02:11:22) Fertility & Human Disease; 3-Parent In Vitro Fertilization (IVF); RNA Testing (02:17:56) Deliberate Cold Exposure, Learning & Memory (02:29:26) Zero-Cost Support, Spotify & Apple Reviews, YouTube Feedback, Sponsors, Momentous, Social Media, Neural Network Newsletter Disclaimer Learn more about your ad choices. Visit megaphone.fm/adchoices

Weaze the juice…it’s Brendan Fraser. Items you’ll need for this ep: a punch card, a video magnetofon, prison WIFI, pork and beans, and a hidden Yorkshire Terrier. Safety first; it’s SmartLess. Please support us by supporting our sponsors.

I hit 700k Subscribers on YouTube!! To celebrate, I asked for questions from YouTube, Twitter, Locals and Instagram, so here's another 90 minutes of me trying to answer as many as possible. As always there's some great questions in here about whether Ray Dalio is coming on the podcast, how to overcome negative self talk and whether I'll be doing a live tour soon. Expect to learn how I deal with nerves before big podcasts, my very simple memorisation tactic for the books I read, whether I class myself as anti-woke, if I think young men should leave the dating market all together right now, why I stopped working as a model, what t-shirts I always wear, whether I'm worried about EMFs from AirPods, my favourite chest day routine and much more... Sponsors: Get $100 off plus an extra 15% discount on Qualia Mind at https://neurohacker.com/modernwisdom (use code MW15) Get 7 days free access and 25% discount from Blinkist at https://blinkist.com/modernwisdom (use code MODERNWISDOM) Get $250 discount on Sacred Hunting’s trips at https://www.sacredhunting.com/modernwisdom Extra Stuff: Get my free Reading List of 100 books to read before you die → https://chriswillx.com/books/ To support me on Patreon (thank you): https://www.patreon.com/modernwisdom - Get in touch. Instagram: https://www.instagram.com/chriswillx Twitter: https://www.twitter.com/chriswillx YouTube: https://www.youtube.com/modernwisdompodcast Email: https://chriswillx.com/contact/  Learn more about your ad choices. Visit megaphone.fm/adchoices