🇺🇸 United States Episodes

Adam D’Angelo (Quora/Poe) thinks we're 5 years from automating remote work. Amjad Masad (Replit) thinks we're brute-forcing intelligence without understanding it. In this conversation, two technical founders who are building the AI future disagree on almost everything: whether LLMs are hitting limits, if we're anywhere close to AGI, and what happens when entry-level jobs disappear but experts remain irreplaceable. They dig into the uncomfortable reality that AI might create a "missing middle" in the job market, why everyone in SF is suddenly too focused on getting rich to do weird experiments, and whether consciousness research has been abandoned for prompt engineering. Plus: Why coding agents can now run for 20+ hours straight, the return of the "sovereign individual" thesis, and the surprising sophistication of everyday users juggling multiple AIs.

On Wednesday, the Supreme Court heard oral arguments in a case that could reverse President Trump’s sweeping tariffs, and potentially upend the central piece of his economic policy. WSJ’s James Romoser breaks down the case on both sides and explains why some conservative justices are skeptical of Trump administration’s argument for the tariffs. Ryan Knutson hosts. Further Listening: The Supreme Court’s Season Finale, Explained Trump 2.0: A Showdown With the Judiciary Sign up for WSJ’s free What’s News newsletter.  Learn more about your ad choices. Visit megaphone.fm/adchoices

When conservationists talk about rewilding, most people picture wolves and bison roaming endless landscapes — but Isabella Tree discovered the real revolution is happening in ordinary backyards. She shares the incredible story of how she and her husband transformed their failing farmland into a nature paradise, offering a three-step formula for anyone looking to turn their green space wild. Hosted on Acast. See acast.com/privacy for more information.

Today’s guests are Priscilla Chan and Mark Zuckerberg, co-founders of Biohub (fka Chan Zuckerberg Initiative). They are one of the leading institutes for AI x Bio and open science research with projects like CELLxGENE, rbio1, VariantFormer, and many more. We talked about the evolution from a broad philanthropic institute to specializing in frontier AI + bio, why they are building 12ft tall microscopes to gather better data, and how building a virtual cell model + virtual immune system could potentially help us cure all diseases. Chapters 00:00:00 Introduction and CZI's 10-Year Anniversary 00:00:56 Learning from Bill Gates 00:04:05 Science vs Translation 00:10:45 The Power of Physical Proximity in Science 00:13:55 Building the Virtual Cell: From Data to Models 00:15:51 Microscopes, Imaging, and Converting Atoms to Bits 00:23:18 AI Meets Biology: The Frontier Lab Concept 00:27:25 How Models Can Enable More Ambitious Research 00:30:15 Precision Medicine and Clinical Impact 00:45:17 The Virtual Immune System and Cellular Engineering 00:48:27 Accelerating the Timeline: What It Takes to Cure All Disease 00:28:45 Joining Forces with Evolutionary Scale

Priscilla Chan and Mark Zuckerberg join a16z’s Ben Horowitz, Erik Torenberg, and Vineeta Agarwala to share how the Chan Zuckerberg Initiative is building the computational tools that will accelerate the cure, prevention, and management of all disease by century's end. They explain why basic science needs $100 million-scale projects that traditional NIH grants can't fund, how their Cell Atlas became biology's missing periodic table with millions of cells catalogued in open-source format, and why their new virtual cell models will let scientists test high-risk hypotheses in silico before investing in expensive wet lab work. Plus: the organizational shift unifying the Biohub under AI leadership, what happens when biologists and engineers sit side-by-side, and why modern biology labs are expanding compute instead of square footage.

It isn't always easy to feel like you can have it all: career, family, hobbies and inner peace. Harvard professor Arthur C. Brooks studies happiness and says it is a direction, not a destination. Brooks believes happiness is especially important for leaders, as the higher you climb the more stressful the job can get - and the wider impact you can have on others. Live in conversation at Harvard Business School's Klarman Hall, he speaks with IdeaCast host and HBR editor at large Adi Ignatius about the importance of empathy and having a greater purpose in your life, not just in your career. Brooks is author of the book The Happiness Files: Insights on Work and Life.

Snowflake is moving beyond the data warehouse. Its new Snowflake Intelligence is an agentic platform for every employee, not just data teams. Sarah Guo sits down with Snowflake CEO Sridhar Ramaswamy to discuss his first 18 months at the helm, as well as the massive pivot to make the data giant AI-first. Sridhar talks about Snowflake Intelligence, the company's new AI agent platform, and its implications for enterprise data management. They also explore how Sridhar navigates partnerships with major tech companies, how he fosters a culture of continuous improvement within the organization, and how he envisions Snowflake’s future as an integral data-driven enterprise solution.  Sign up for new podcasts every week. Email feedback to [email protected] Follow us on Twitter: @NoPriorsPod | @Saranormous | @EladGil | @Snowflake Chapters: 00:00 – Sridhar Ramaswamy Introduction 00:42 – Snowflake’s Market Adaptation 03:14 – Snowflake’s Evolution and AI Integration 05:44 – Introducing Snowflake Intelligence 09:01 – Snowflake Intelligence User Experience 11:55 – Drawing the Line Between Data, Agent System, and App 13:30 – Leadership and Organizational Changes 16:19 – How Being an Investor, Entrepreneur Informed Sridhar’s Leadership 18:50 – Importance of Product-Market Fit 22:46 – Snowflake’s Strategic Positioning 27:10 – Snowflake’s Partnership Strategy 30:20 – How Sridhar Sees the ROI of AI 35:09 – How AI Changes the Ad Model 38:15 – Why LLMs Still Need Search 42:11 – Conclusion

She built her first company, Bobbi Brown Cosmetics, into a billion-dollar brand. But when things soured between her and her parent company, Estée Lauder, she had a choice: retire from the industry, or reinvent herself with a new brand. Brown joins host Jeff Berman to reveal the lessons she learned from scaling – and leaving – her first company. She’s leveraging those decades of insights now in her new venture: Jones Road Beauty. Still Bobbi: https://www.simonandschuster.com/books/Still-Bobbi/Bobbi-Brown/9781668082171Subscribe to the Masters of Scale weekly newsletter: https://mastersofscale.com/subscribeSee Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

In this Huberman Lab Essentials episode, I explore the neuroscience of fear and trauma and how to effectively process and eliminate traumatic responses. I explain why successful fear treatment requires both extinction of the old fearful response and replacement with a new positive association—not just cognitive reframing. I also explain how the threat reflex activates specific circuits connecting the amygdala, prefrontal cortex, and dopamine systems, and why detailed recounting of traumatic events progressively reduces their physiological impact. Finally, I review evidence-based approaches, including prolonged exposure therapy and cognitive behavioral therapy, discuss how five minutes per day of deliberate stress through cyclic hyperventilation can rewire fear responses, explain the critical role of social connection in activating neural pathways that reduce trauma, and share supplementation options for managing anxiety. Read the episode show notes at hubermanlab.com. Thank you to our sponsors AGZ by AG1: https://drinkagz.com/huberman LMNT: https://drinklmnt.com/huberman Function: https://functionhealth.com/huberman Timestamps (0:00) Introducing Fear & Trauma (0:17) What is Fear? (1:03) Autonomic Arousal: "Alertness" vs. "Calmness" (2:05) Fear vs. Stress & Anxiety (9:20) "The Threat Reflex": Neural Circuits for Fear (20:50) Cognitive (Narrative) Therapies for Fear (26:35) PTSD Treatments: Ketamine, MDMA, Oxytocin (33:11) Deliberate Brief Stress Can Erase Fears & Trauma (35:51) Nutrition, Sleep, & Other General Support Erasing Fear & Trauma (38:18) Recap Disclaimer & Disclosures Learn more about your ad choices. Visit megaphone.fm/adchoices

Sean Hayes (from SmartLess, one of our podcast dads) is here! We get into Gleem toothpaste commercials and weird 1-800 hotlines, and give Jenny advice on a meme featuring her getting some seriously unwanted attention. Plus: hear Gabe and Max try out their Delco accents. You can call us with your etiquette question and leave a voicemail at 949-441-1231, or email us at [email protected]! Follow us on Instagram and TikTok @ineedyouguysshow Subscribe to our YouTube channel to watch full video episodes. I Need You Guys with Gabe Liedman, Jenny Slate and Max Silvestri is a production of SmartLess Media. Produced by Anne Harris, Josh Richmond and Devon Torrey Bryant. Edited by Josh, with music by Devon. Executive Producers are Gabe, Jenny and Max. Executive Producers for SmartLess Media are Will Arnett, Jason Bateman, Sean Hayes, Richard Korson and Bernie Kaminski.

Rob Henderson holds a PhD in psychology from the University of Cambridge and is a Senior Fellow at the Manhattan Institute. When did having a boyfriend become cringe? For as long as men have been men and women have been women, finding a partner to share life with has been one of humanity’s oldest goals. So what changed? Why has wanting connection become something to mock, and what can be done to reverse it Sponsors: See discounts for all the products I use and recommend: https://chriswillx.com/deals Get Free Travel Packs, Free Liquid Vitamin D, and more from AG1 at https://ag1.info/modernwisdom Get up to $50 off the RP Hypertrophy App at https://rpstrength.com/modernwisdom Get 60% off an annual plan of Incogni at https:/incogni.com/modernwisdom Extra Stuff: Get my free reading list of 100 books to read before you die: https://chriswillx.com/books Try my productivity energy drink Neutonic: https://neutonic.com/modernwisdom Episodes You Might Enjoy: #577 - David Goggins - This Is How To Master Your Life: https://tinyurl.com/43hv6y59 #712 - Dr Jordan Peterson - How To Destroy Your Negative Beliefs: https://tinyurl.com/2rtz7avf #700 - Dr Andrew Huberman - The Secret Tools To Hack Your Brain: https://tinyurl.com/3ccn5vkp - Get In Touch: Instagram: https://www.instagram.com/chriswillx Twitter: https://www.twitter.com/chriswillx YouTube: https://www.youtube.com/modernwisdompodcast Email: https://chriswillx.com/contact - Learn more about your ad choices. Visit megaphone.fm/adchoices

If Lindsey Graham gets re-elected to the US Senate, there’s no reason to have a Republican Party. Here’s how to stop it. (00:00) Monologue (45:23) Why Paul Dans Decided to Run Against Lindsey Graham (1:00:01) How Globalism Destroyed the United States (1:18:57) How Does Lindsey Graham Keep Getting Reelected? (1:24:55) How Much Money Has Lindsey Graham Made Since Being a Senator? (1:27:43) Lindsey Graham's Strange Psychosexual Relationship to Violence Paid partnerships with: Beam: Go to https://ShopBeam.com/Tucker use code TUCKER and get up to 50% off during Beam's Cyber Sale.  Byrna: Go to https://Byrna.com or your local Sportsman's Warehouse today.Preborn: To donate please dial #250 and say keyword "BABY" or visit https://preborn.com/TUCKERPureTalk: Go to https://PureTalk.com/Tucker to and save 50% off your first month. Paul Dans is the primary challenger to Lindsey Graham for Senate in South Carolina. He was previously the chief architect of Project 2025 and worked on all the Trump campaigns and in the 2017 administration. Follow him on X @DansForSenate and find out more about him or donate at PaulDans.com. Learn more about your ad choices. Visit megaphone.fm/adchoices

(0:00) Introducing Ari Emanuel (1:03) Ari's background in the content business and Hollywood (4:14) How infinite distribution is changing Hollywood, the future of podcasting, creators owning advertising products (9:21) AI's impact: anticipating the 3-day workweek (12:13) Splitting time between TKO and WME, YouTube vs Netflix for creators, modern IP ownership (18:20) How he got a fighter's reputation, relationship with Michael Ovitz, how he built on Ovitz's vision (22:12) Future of sports entertainment: adapting to attention spans, clip culture, going global (24:21) Ari's relationship with his brothers and Elon Musk Thanks to our partners for making this happen! Solana - Solana is the high performance network powering internet capital markets, payments, and crypto applications. Connect with investors, crypto founders, and entrepreneurs at Solana's global flagship event during Abu Dhabi Finance Week & F1: https://solana.com/breakpoint OKX - The new way to build your crypto portfolio and use it in daily life. We call it the new money app. https://www.okx.com/ Google Cloud - The next generation of unicorns is building on Google Cloud's industry-leading, fully integrated AI stack: infrastructure, platform, models, agents, and data. https://cloud.google.com/ IREN - IREN AI Cloud, powered by NVIDIA GPUs, provides the scale, performance, and reliability to accelerate your AI journey. https://iren.com/ Oracle - Step into the future of enterprise productivity at Oracle AI Experience Live. https://www.oracle.com/artificial-intelligence/data-ai-events/ Circle - The America-based company behind USDC — a fully-reserved, enterprise-grade stablecoin at the core of the emerging internet financial system. https://www.circle.com/ BVNK - Building stablecoin-powered financial infrastructure that helps businesses send, store, and spend value instantly, anywhere in the world. https://www.bvnk.com/ Polymarket - The world's largest prediction market. https://www.polymarket.com/ Follow Ari: https://x.com/AriEmanuel Follow the besties: https://x.com/chamath https://x.com/Jason https://x.com/DavidSacks https://x.com/friedberg Follow on X: https://x.com/theallinpod Follow on Instagram: https://www.instagram.com/theallinpod Follow on TikTok: https://www.tiktok.com/@theallinpod Follow on LinkedIn: https://www.linkedin.com/company/allinpod Intro Music Credit: https://rb.gy/tppkzl https://x.com/yung_spielburg

At WSJ’s Tech Live, Jessica Mendoza sits down with Michael Kratsios, Director of the White House Office of Science and Technology Policy to discuss the pivotal moment in the U.S.-China AI race, how he thinks AI should be regulated, and whether or not the AI boom might be a bubble.  Further Listening: - Is the AI Boom… a Bubble? - How a $1.5 Billion Settlement Could Alter the Course of AI  - The Nvidia CEO’s Quest to Sell Chips in China Sign up for WSJ’s free What’s News newsletter. Learn more about your ad choices. Visit megaphone.fm/adchoices

Russell Crowe is an Academy Award–winning actor, director, and vocalist of the band Indoor Garden Party. His latest film role is that of Nazi war criminal Hermann Göring in the historical drama “Nuremberg,” which premieres in theaters on November 7. https://www.sonyclassics.com/film/nuremberg/www.indoorgardenparty.com Perplexity: Download the app or ask Perplexity anything at https://pplx.ai/rogan. Try ZipRecruiter FOR FREE at https://ziprecruiter.com/rogan Get Gameday Deals all season long only on Uber Eats. Order Now. Learn more about your ad choices. Visit podcastchoices.com/adchoices

What if the next Lionel Messi or Simone Biles is out there right now ... but no one knows? Sports scientist Richard Felton-Thomas shows how new AI tools are expanding the reach of talent discovery in sports, helping scouts find the next great superstar — and letting athletes showcase their skills from anywhere in the world. Hosted on Acast. See acast.com/privacy for more information.

Get the guide to build your own unicorn billion dollar biz: https://clickhubspot.com/fgk Episode 761: Shaan Puri ( ⁠https://x.com/ShaanVP⁠ ) sits down with Ryan Smith ( https://x.com/ryanqualtrics ) – the high school dropout who built an $8B company and bought an NBA team. — Show Notes: (0:00) 1.9 GPA to $2B (9:47) Starting Qualtrics (14:02) Focus (24:00)  How to be top 1% at sales (26:17) Turning down $500M (31:37) Working backwards (3814) Buying an NBA team (43:51)  The 9 most important minutes of the day — Links: • Qualtrics - https://www.qualtrics.com/ • Utah Jazz - https://www.nba.com/jazz/ — Check Out Shaan's Stuff: • Shaan's weekly email - https://www.shaanpuri.com  • Visit https://www.somewhere.com/mfm to hire worldwide talent like Shaan and get $500 off for being an MFM listener. Hire developers, assistants, marketing pros, sales teams and more for 80% less than US equivalents. • Mercury - Need a bank for your company? Go check out Mercury (mercury.com). Shaan uses it for all of his companies! Mercury is a financial technology company, not an FDIC-insured bank. Banking services provided by Choice Financial Group, Column, N.A., and Evolve Bank & Trust, Members FDIC — Check Out Sam's Stuff: • Hampton - https://www.joinhampton.com/ • Ideation Bootcamp - https://www.ideationbootcamp.co/ • Copy That - https://copythat.com • Hampton Wealth Survey - https://joinhampton.com/wealth • Sam’s List - http://samslist.co/ My First Million is a HubSpot Original Podcast // Brought to you by HubSpot Media // Production by Arie Desormeaux // Editing by Ezra Bakker Trupiano

Eugenia Kuyda, CEO of Wabi and AI pioneer behind Replika, joins Erik, Anish, and Justine to reveal how personal software will transform from a developer monopoly to a creative medium for all. She exposes why command-line AI interfaces are the new MS-DOS, explains how mini-apps will become as shareable as TikToks, and details her decade-long journey from training language models in 2012 to building the platform where your mom can create custom apps in minutes. Plus: untold stories from OpenAI's apartment days and why voice-only devices completely miss the point.

People in the U.S. are feeling the financial squeeze, in part because of rising inflation, higher consumer prices and slowing job growth. The Indicator from Planet Money is tackling a special series on the rising cost of living. Today, two stories from that series. First, what’s making ticket prices go up? We look at the economics behind the ticket market and how “reseller bots” are wreaking all sorts of havoc. The industry is not a fan, and yet they do serve an economic function. And… why pet care costs have surged. It comes down to unique skills, people’s love for their pets and something called the “Baumol effect.” Related episodes: - The Vet Clinic Chow Down - What Do Private Equity Firms Actually Do?  - Kid Rock vs. The Scalpers - Ticket scalpers: The real ticket masters Subscribe to Planet Money+ Listen free: Apple Podcasts, Spotify, the NPR app or anywhere you get podcasts.Facebook / Instagram / TikTok / Our weekly Newsletter. This episode is hosted by Darian Woods, Adrian Ma, and Wailin Wong. These episodes of The Indicator were originally produced by Angel Carreras. Cooper Katz McKim produced this episode. It was engineered by Robert Rodriguez and fact-checked by Sierra Juarez. Kate Concannon is The Indicator’s editor. Alex Goldmark is Planet Money's executive producer. Learn more about sponsor message choices: podcastchoices.com/adchoicesNPR Privacy Policy