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ElevenLabs CEO and co‑founder Mati Staniszewski joins Jennifer Li to explain how the team ships research‑grade AI at lightning speed—from text‑to‑speech and fully licensed AI music to real‑time voice agents—and why voice is the next interface for human‑computer interaction. He shares the small, autonomous team model, global hiring approach, and how the Voice Marketplace has paid creators over $10M while evolving into an enterprise platform.

(0:00) Introducing Tareq Amin (0:39) Saudi Arabia's evolution, Humain's business (8:11) How Humain works with foundational model providers (13:14) Saudi's energy and talent advantages, the AI race in the Middle East (18:11) Working in the era of MBS, Vision 2030 (21:40) How Saudi manages their relationships with the US and China (23:51) Sacks on the US-Saudi AI alliance Thanks to our partners for making this happen! Solana - Solana is the high performance network powering internet capital markets, payments, and crypto applications. Connect with investors, crypto founders, and entrepreneurs at Solana's global flagship event during Abu Dhabi Finance Week & F1: https://solana.com/breakpoint OKX - The new way to build your crypto portfolio and use it in daily life. We call it the new money app. https://www.okx.com/ Google Cloud - The next generation of unicorns is building on Google Cloud's industry-leading, fully integrated AI stack: infrastructure, platform, models, agents, and data. https://cloud.google.com/ IREN - IREN AI Cloud, powered by NVIDIA GPUs, provides the scale, performance, and reliability to accelerate your AI journey. https://iren.com/ Oracle - Step into the future of enterprise productivity at Oracle AI Experience Live. https://www.oracle.com/artificial-intelligence/data-ai-events/ Circle - The America-based company behind USDC — a fully-reserved, enterprise-grade stablecoin at the core of the emerging internet financial system. https://www.circle.com/ BVNK - Building stablecoin-powered financial infrastructure that helps businesses send, store, and spend value instantly, anywhere in the world. https://www.bvnk.com/ Polymarket - The world's largest prediction market. https://www.polymarket.com/ Follow Tareq: https://x.com/TareqAmin_ Follow the besties: https://x.com/chamath https://x.com/Jason https://x.com/DavidSacks https://x.com/friedberg Follow on X: https://x.com/theallinpod Follow on Instagram: https://www.instagram.com/theallinpod Follow on TikTok: https://www.tiktok.com/@theallinpod Follow on LinkedIn: https://www.linkedin.com/company/allinpod Intro Music Credit: https://rb.gy/tppkzl https://x.com/yung_spielburg

The debate over healthcare subsidies has shut down the federal government for a historic length of time. With open enrollment underway, many Americans who pay for plans under the Affordable Care Act are experiencing sticker shock. Some costs have doubled, tripled, or even quintupled. WSJ’s Anna Wilde Matthews takes us inside the hefty premium hikes and explains why the high price tag could have an impact on the system as a whole. Ryan Knutson hosts. Further Listening: -The Healthcare Costs of Trump's Big Beautiful Bill -Medicare, Inc. Part 1: How Insurers Make Billions From Medicare -Medicare Inc. Part 2: Taxpayers Paid for care Denied by Insurers Sign up for WSJ’s free What’s News newsletter. Learn more about your ad choices. Visit megaphone.fm/adchoices

Luis J. Gomez and Big Jay Oakerson are comics and podcasters. Together, they host “Story Warz” and “Legion of Skanks” with Dave Smith. Luis also hosts “Real Ass Podcast” with Zac Amico, and Big Jay hosts “The Bonfire” on SiriusXM with Robert Kelly. Big Jay’s two-part crowdwork special, “Them/They,” is available on YouTube and vinyl, and Luis’s new special, “You’re Making This Worse,” premieres on YouTube on November 2.www.luisofskanks.comwww.youtube.com/@LuisJGomezComedywww.bigjaycomedy.comwww.youtube.com/@bigjayoakerson https://800poundgorillamedia.com/pages/bigjay Perplexity: Download the app or ask Perplexity anything at https://pplx.ai/rogan. Don’t miss out on all the action - Download the DraftKings app today! Sign-up at https://dkng.co/rogan or with my promo code ROGAN GAMBLING PROBLEM? CALL 1-800-GAMBLER, (800) 327-5050 or visit gamblinghelplinema.org (MA). Call 877-8-HOPENY/text HOPENY (467369) (NY). Please Gamble Responsibly. 888-789-7777/visit ccpg.org (CT), or visit www.mdgamblinghelp.org (MD). 21+ and present in most states. (18+ DC/KY/NH/WY). Void in NH/OR/ONT. Eligibility restrictions apply. Terms: draftkings.com/sportsbook. On behalf of Boot Hill Casino & Resort (KS). Fees may apply in IL. 1 per new DraftKings customer. Must register new DraftKings account to receive reward Token. Must select Token BEFORE placing min. $5 bet to get 1 promo code to redeem complimentary 3-month NBA League Pass subscription, and max. $300 in Bonus Bets if your bet wins. Min. -500 odds req. Token and Bonus Bets are single-use and non-withdrawable. Bonus Bet expires in 7 days (168 hours) and stake removed from payout. Token expires 11/23/25. Terms: sportsbook.draftkings.com/promos. NBA League Pass: Subscription auto-renews monthly at then-current price (currently $16.99/mo); cancel anytime. Terms, restrictions, and eligibility requirements apply. Redeem League Pass by 12/19/25 This video is sponsored by BetterHelp. Visit https://BetterHelp.com/JRE Learn more about your ad choices. Visit podcastchoices.com/adchoices

What if you had an AI-powered assistant — that took initiative on its own? Technology leader Swami Sivasubramanian believes AI agents are the future of work, capable of sparking new levels of productivity and creativity. Demystifying the workings of autonomous software systems, he explains what they are (and aren’t) and advocates for a world in which AI handles the boring stuff, so you can focus on what matters. Hosted on Acast. See acast.com/privacy for more information.

How to identify and rewrite the limiting beliefs holding you back.Achieving what you want in life doesn’t just hinge on what you believe about your future. According to Muriel Wilkins, it has just as much to do with what you believe about your past and present.Wilkins is an executive coach, author, and host of the HBR podcast Coaching Real Leaders. In her new book, Leadership Unblocked: Breakthrough the Beliefs that Limit Your Potential, she explains how our personal and professional blocks often stem from our own limiting beliefs about ourselves. “A belief is a story that you tell yourself,” she says, “It is the operating principle that is driving your behavior and the decisions you make.” Before we can take actions that will lead us to where we want to go, we have to uncover these hidden beliefs. Otherwise, Wilkins says, “We'll come back right to where we started. It's not just about what we do, it's about what we think about what we do that makes all the difference."In this episode of Think Fast, Talk Smart, Wilkins and host Matt Abrahams explore the three-step process of uncover, unpack, and unblock — Wilkins’ method for identifying limiting beliefs, understanding how they might be shaping our behavior, and updating narratives to align with who we actually want to be.To listen to the extended Deep Thinks version of this episode, please visit FasterSmarter.io/premium.Episode Reference Links:Muriel WilkinsMuriel’s Book: Leadership UnblockedEp.102 Create a Presence: How to Communicate in a Way Others Can FeelEp.98 Give It to Me Straight: How to Give Honest, Constructive Feedback  Connect:Premium Signup >>>> Think Fast Talk Smart PremiumEmail Questions & Feedback >>> [email protected] Transcripts >>> Think Fast Talk Smart WebsiteNewsletter Signup + English Language Learning >>> FasterSmarter.ioThink Fast Talk Smart >>> LinkedIn, Instagram, YouTubeMatt Abrahams >>> LinkedInChapters:(00:00) - Introduction (02:56) - The Seven Limiting Beliefs (05:22) - Three Steps to Becoming Unblocked (08:36) - Rethinking Values and Success (09:51) - Healthy vs. Toxic Productivity (12:35) - The Power of Mindset and Reframing (15:11) - Reverse Engineering Your Goals (18:20) - Managing Emotional Investment (22:00) - The Final Three Question (27:40) - Conclusion ********Thank you to our sponsors.  These partnerships support the ongoing production of the podcast, allowing us to bring it to you at no cost. Go to Quince.com/ThinkFast for free shipping on your order and 365-day returns. Join our Think Fast Talk Smart Learning Community and become the communicator you want to be.

When Wikipedia was founded in 2001, the idea that people around the world could come together to create an accurate online encyclopedia covering virtually any topic seemed far-fetched. But today many people see the website as a trusted source of well-curated and -cited information. That's because of careful decisions that its leaders made about how to operate. Cofounder Jimmy Wales explains how introducing a simple purpose, insisting on certain rules of engagement, and other strategies helped the organization to build trust with contributors and users -- and maintain it even in a world bombarded by misinformation. Wales is the author of The Seven Rules of Trust: A Blueprint for Building Things That Last.

In a special episode of Rapid Response, we feature two fast-paced, lively conversations from Masters of Scale Summit in San Francisco. Autodesk CMO Dara Treseder breaks down branding and marketing lessons from the most high-profile campaigns of 2025. Treseder shares her unvarnished read on Sydney Sweeney, Cracker Barrel, Taylor Swift, and more. In the second half of the episode, Flexport CEO Ryan Petersen assesses the five biggest myths around trade and tariffs today, advises about avoiding jail, and what he calls "dumb competition."Visit the Rapid Response website here: https://www.rapidresponseshow.com/See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

My guest today is Luca Ferrari. Luca is the co-founder and CEO of Bending Spoons, which he describes as 25 percent private equity and 75 percent technology company. Founded in 2013, Bending Spoons fully acquires and operates digital companies like Evernote, Meetup, Vimeo, and most recently AOL.  Our conversation explores the unique model behind Bending Spoons, and the culture required to scale it. Luca shares exactly how their acquisition playbook works – from identifying promising businesses to rebuilding every part of them across product, design, monetization, and marketing. We discuss their approach to financing long-term ownership through both debt and equity, Luca’s obsession with finding and developing exceptional talent, and his decision to build the company in Europe.  I found Luca’s description of himself as perennially unhappy to be the clearest window into how he builds. It’s a mindset that fuels his pursuit of excellence and defines the culture at Bending Spoons. Please enjoy my conversation with Luca Ferrari. For the full show notes, transcript, and links to mentioned content, check out the episode page ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠here⁠⁠⁠⁠⁠⁠⁠⁠.⁠⁠⁠⁠⁠⁠⁠⁠ ----- This episode is brought to you by⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ Ramp⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠. Ramp’s mission is to help companies manage their spend in a way that reduces expenses and frees up time for teams to work on more valuable projects. Go to⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ Ramp.com/invest⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ to sign up for free and get a $250 welcome bonus. – This episode is brought to you by⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ AlphaSense⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠. AlphaSense has completely transformed the research process with cutting-edge AI technology and a vast collection of top-tier, reliable business content. Invest Like the Best listeners can get a free trial now at⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ Alpha-Sense.com/Invest⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ and experience firsthand how AlphaSense and Tegus help you make smarter decisions faster. –- This episode is brought to you by⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ Ridgeline⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠. Ridgeline has built a complete, real-time, modern operating system for investment managers. It handles trading, portfolio management, compliance, customer reporting, and much more through an all-in-one real-time cloud platform. Head to⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ ridgelineapps.com⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ to learn more about the platform. ----- Editing and post-production work for this episode was provided by The Podcast Consultant (⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://thepodcastconsultant.com⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠). Show Notes: (00:00:00) Welcome to Invest Like the Best (00:03:12) The Vision and Ambition (00:07:56) Challenges and Early Days (00:11:01) The Turning Point: Evertale to Bending Spoons (00:13:12) Acquisition Strategy and Growth (00:24:22) Case Study: Evernote Acquisition (00:33:34) Pricing and Valuation Insights (00:40:02) Making Competitive Offers (00:40:37) Walkaway Rate and Offer Success (00:41:14) Financing the Business (00:43:21) Lessons from Acquisitions (00:46:32) The AOL Acquisition (00:48:21) Simplifying Business Operations (00:56:10) Incentives and Motivation (00:58:31) Balancing Discontent and Growth (01:03:21) Raising Debt Capital (01:06:37) Impact of AI on Business (01:11:00) Company Culture and Traditions (01:16:00) The Kindest Thing

Louis sits down with David Byrne, the musician, author and iconic frontman of Talking Heads. David tells Louis about personality clashes within the band, how his neurodivergence plays a role in his music, and being at the centre of a culture-war storm. Plus, they discuss whether Donald Trump stole his ‘big suit’. Warnings: Strong language and adult themes.     Links/Attachments:   Book: Bicycle Diaries, David Byrne (2009)  https://www.waterstones.com/book/bicycle-diaries/david-byrne/9780571371266     Album: Who Is The Sky, David Byrne (2025)  https://open.spotify.com/album/5xDqZQlSx2gRrAyAgHQ8AB     Song: ‘The Book I Read’, Talking Heads (1977)  https://open.spotify.com/track/4OT7Ndu29Z7JfhwRS2iCJX     Song: ‘That’s the Way (I Like It), KC & The Sunshine Band (1994)  https://open.spotify.com/track/0RQTbMBgSq7xgdZSHFZg4R      Book: ‘An Anthropologist on Mars’, Oliver Sacks (1995)  https://www.oliversacks.com/oliver-sacks-books/an-anthropologist-on-mars/     Song: ‘She Explains Things To Me’, David Byrne (2025) https://open.spotify.com/album/5f6f5JMGxgNa0LAJqtaUXY      Song: ‘Psycho Killer’, Talking Heads (1977)  https://open.spotify.com/track/7dSCxR4LqkmxoBrq9MzVSD     Artist: Randy Newman  https://open.spotify.com/artist/3HQyFCFFfJO3KKBlUfZsyW    Artist: Alice Cooper   https://open.spotify.com/artist/3EhbVgyfGd7HkpsagwL9GS     Album: Talking Heads 77, Talking Heads (1977) https://open.spotify.com/album/0r7o2FeARRr23EZ0TJ0a8S     Artist: Ramones   https://open.spotify.com/artist/1co4F2pPNH8JjTutZkmgSm     Artist: The Clash   https://open.spotify.com/artist/3RGLhK1IP9jnYFH4BRFJBS     Artist: Sex Pistols   https://open.spotify.com/artist/1u7kkVrr14iBvrpYnZILJR     2002 Rock & Roll Hall of Fame Talking Heads performance: https://www.youtube.com/watch?v=bBr0FJsDk1g    Stop Making Sense (1984)  https://tv.apple.com/gb/movie/stop-making-sense/umc.cmc.4qcn1p5rridjzo742xirf9j8m     The Silence of the Lambs (1991)  https://tv.apple.com/gb/movie/the-silence-of-the-lambs/umc.cmc.vo1hrvp25kr64fq8irp5jx75?action=play     True Stories (2016)  https://tv.apple.com/gb/movie/true-stories/umc.cmc.7ffwwfhraf765c0l9l1v7a4tw?action=play     Weekly World News:  https://weeklyworldnews.com/     David’s online magazine:   https://reasonstobecheerful.world/      Credits:  Producer: Millie Chu   Assistant Producer: Artemis Irvine  Production Manager: Francesca Bassett   Music: Miguel D’Oliveira   Audio Mixer: Tom Guest  Video Mixer: Scott Edwards   Shownotes compiled by Elly Young  Executive Producer: Arron Fellows       A Mindhouse Production for Spotify   www.mindhouse.co.uk   Learn more about your ad choices. Visit podcastchoices.com/adchoices

The historic Waldorf Astoria Hotel has reopened after an eight year saga that went $1 billion over budget. WSJ’s Craig Karmin takes us inside the deal to buy the hotel, the arrest of its new owner and the Chinese government’s takeover. Ryan Knutson hosts. Further Listening:- Six Days of Chaos at MGM’s Casinos- The Missing Minister Sign up for WSJ’s free What’s News newsletter. Learn more about your ad choices. Visit megaphone.fm/adchoices

The moment our leaders started pretending that gender roles aren’t deeply embedded in nature, the West fell apart. Chris Williamson explains. (00:00) Should You Go to College? (12:58) The Real Wage Gap Between Men and Women (19:37) Why Female Happiness Is in Decline (36:32) Where Did the Phrase "Toxic Masculinity" Come From? (45:28) The Efforts to Subdue Men With Porn, Video Games and Weed (54:29) Why Is Suicide Skyrocketing? (1:10:24) What Is the Fundamental Role of a Spouse? Paid partnerships with: Poncho Outdoors: Go to PonchoOutdoors.com/Tucker and enter your email for $10 off your first order Black Rifle Coffee: Promo code "Tucker" for 30% off at https://www.blackriflecoffee.com Learn more about your ad choices. Visit megaphone.fm/adchoices

(0:00) Introducing Paul "Triple H" Levesque (0:56) The skills needed to be an effective professional wrestler, understanding the characteristics of President Trump and The Rock (5:41) The rise of the antihero / heel persona, and why modern wrestling is more morally grey (8:43) WWE vs UFC: Why they are opposites, star building (11:21) Physicality of the WWE and how they support wrestlers (14:13) The business of the WWE: using streaming and social as a funnel for live events, the magic of live WWE (21:28) Helping America's youth via physical fitness (23:35) How the internet forced wrestlers to blend their in ring personas with real-life Thanks to our partners for making this happen! Solana - Solana is the high performance network powering internet capital markets, payments, and crypto applications. Connect with investors, crypto founders, and entrepreneurs at Solana's global flagship event during Abu Dhabi Finance Week & F1: https://solana.com/breakpoint OKX - The new way to build your crypto portfolio and use it in daily life. We call it the new money app. https://www.okx.com/ Google Cloud - The next generation of unicorns is building on Google Cloud's industry-leading, fully integrated AI stack: infrastructure, platform, models, agents, and data. https://cloud.google.com/ IREN - IREN AI Cloud, powered by NVIDIA GPUs, provides the scale, performance, and reliability to accelerate your AI journey. https://iren.com/ Oracle - Step into the future of enterprise productivity at Oracle AI Experience Live. https://www.oracle.com/artificial-intelligence/data-ai-events/ Circle - The America-based company behind USDC — a fully-reserved, enterprise-grade stablecoin at the core of the emerging internet financial system. https://www.circle.com/ BVNK - Building stablecoin-powered financial infrastructure that helps businesses send, store, and spend value instantly, anywhere in the world. https://www.bvnk.com/ Polymarket - The world's largest prediction market. https://www.polymarket.com/ Follow Triple H: https://x.com/TripleH Follow the besties: https://x.com/chamath https://x.com/Jason https://x.com/DavidSacks https://x.com/friedberg Follow on X: https://x.com/theallinpod Follow on Instagram: https://www.instagram.com/theallinpod Follow on TikTok: https://www.tiktok.com/@theallinpod Follow on LinkedIn: https://www.linkedin.com/company/allinpod Intro Music Credit: https://rb.gy/tppkzl https://x.com/yung_spielburg

The AI revolution and our aging power grid are on a historic collision course, threatening to stall innovation and raise energy costs for everyone. Physicist and AI grid futurist Varun Sivaram reveals how we might turn this looming crisis into a once-in-a-generation opportunity — unlocking massive power capacity, lowering costs and accelerating the energy future we’ve been waiting for. Hosted on Acast. See acast.com/privacy for more information.

OpenAI recently made waves by being the first big model lab to commit to a hyperscale AMD cluster (together with their own Titan XPUs), giving AMD the first biglab silicon win outside of Nvidia/Google. Returning guest Quentin Anthony, Head of Model Training at Zyphra and advisor at EleutherAI, has recently done this same transition. In part 1 of this pod, Quentin describes his journey from working on Oak Ridge National Lab's Frontier supercomputer to leading Zyphra's ambitious move to AMD MI300X GPUs, where they're achieving performance that beats NVIDIA H100s on certain workloads while dramatically reducing costs. The discussion dives deep into the technical challenges of kernel development, with Quentin explaining why he often bypasses high-level frameworks like Triton to write directly in ROCm or even GPU assembly when necessary. He reveals how Zyphra's hybrid transformer-Mamba models like Zamba 2 can match Llama 3 8B performance at 7B parameters, optimized specifically for edge deployment across a spectrum from 1.2B models for phones to 7B for desktops. In Part 2, Quentin then candidly discusses his experience in the controversial METR software engineering productivity study, which found that developers felt 20% faster while using AI coding tools, but were in fact 20% slower. Quentin was one of the few developers who showed measurable speedup from AI tools. He shares practical insights on avoiding the "slot machine effect" of endlessly prompting models, the importance of context rot awareness, and why he prefers direct API access over tools like Cursor to maintain complete control over model context. The conversation also covers the state of open source AI research, with Quentin arguing that siloed, focused teams with guaranteed funding produce better results than grand collaborative efforts. He explains why kernel datasets alone won't solve the GPU programming problem, the challenges of evaluating kernel quality, and why companies should invest more in ecosystem development rather than traditional marketing. https://www.linkedin.com/in/quentin-anthony/ https://www.zyphra.com/post/zamba2-7b Key Topics: • AMD MI300X advantages: 192GB VRAM, superior memory bandwidth • Writing kernels from PTX/AMD GCN assembly up through CUDA/ROCm • Hybrid attention-Mamba architectures and optimal sparsity ratios • The Menlo productivity study: achieving positive AI speedup • Context rot and why shorter conversations beat long threads • Why physicists make great ML engineers ("embryonic stem cells") • Edge deployment strategies from phones to local clusters • The future of on-device vs cloud inference routing • EleutherAI's focus on interpretability with fully open pipelines • Building velocity-focused teams over position-based hiring

David Sacks, White House AI and Crypto Czar, joins Marc, Ben, and Erik to explore what's really happening inside the Trump administration's AI and crypto strategy. They expose the regulatory capture playbook being pushed by certain AI companies, explain why open source is America's secret weapon, and detail the infrastructure crisis that could determine who wins the global AI race.

My guest is Dr. David Fajgenbaum, MD, professor of translational medicine and human genetics at the University of Pennsylvania. He explains how, unbeknownst to most doctors, many approved medications can successfully treat or even cure diseases other than the ones they are typically used to treat. He shares his story of escaping death from Castleman's disease by discovering a life-saving treatment using repurposed drugs that were approved for other purposes. Our conversation explores how researchers, physicians, and you—the general public—can explore novel treatments and cures to conditions the medical profession has deemed untreatable, including cancers. We also discuss the crucial role of mindset in battling diseases and the lesser-known use of compounds to promote health and longevity. Read the episode show notes at hubermanlab.com. Thank you to our sponsors AGZ by AG1: https://drinkagz.com/huberman Eight Sleep: https://eightsleep.com/huberman Rorra: https://rorra.com/huberman David: https://davidprotein.com/huberman Function: https://functionhealth.com/huberman Timestamps (0:00) David Fajgenbaum (4:06) Self-Agency in Healthcare; New Uses for Old Medicines (6:44) Other Uses of Aspirin & Viagra; Drug Development & Approved Use (8:53) Lidocaine & Breast Cancer; Pharmaceutical Companies & Incentives (11:36) Sponsors: Eight Sleep & Rorra (14:16) Pharmaceutical Companies, Patents & New Uses; Lithium (18:40) Tools: Finding Reliable Health Sources, Asking Questions & Disease Organizations; DADA2 Treatment (21:53) Medical Community & Connections; Integrated Medical Databases (24:36) Drug Repurposing, Thalidomide, Pembrolizumab (28:45) Medical Research Databases, Mapping Disease Connections (33:51) Every Cure Database & Programs, Bachmann-Bupp Syndrome; Colchicine & Heart Disease (37:57) Sponsors: AGZ by AG1 & David (40:41) David’s Medical & Career Journey, Glioblastoma, Castleman Disease (49:10) Autoimmune Disease, Driven Personality, Stress & Immune System (52:52) Castleman Disease, Treatment, Chemotherapy (55:54) Physician Continuing Education, Santa Claus Theory of Civilization; Science Collaboration (1:03:32) Medical School, Relapse & “Overtime”, Finding a New Treatment, Rapamycin (1:12:46) Sport, Football & Resilience; Challenge & Personal Growth, Family (1:18:41) Sponsor: Function (1:20:29) Social Support; “Overtime”, Gratitude (1:23:19) Business School, Castleman Disease Treatment; Repurposing Drugs & AI (1:28:29) Drug Repurposing, POEMS Syndrome; Mitigating Risk (1:35:32) Nicotine, Compounds for Preventive Health; GLP-1 Agonists (1:40:51) Bioprospecting, Drug Development; AI, Prioritization & Novel Connections (1:46:18) Healthcare & Children; Hope, Action & Impact Circuit; Challenge & Super-Agers (1:52:50) Get Involved with Every Cure (1:56:20) Zero-Cost Support, YouTube, Spotify & Apple Follow, Reviews & Feedback, Sponsors, Protocols Book, Social Media, Neural Network Newsletter Disclaimer & Disclosures Learn more about your ad choices. Visit megaphone.fm/adchoices

Ok with the pretzels; it’s David Duchovny. A ship of fools, Dads’ novels, making music, and finalllllly teaching Jason how to read. “I mean, dishwashing liquid is pretty good.” …on an all-new SmartLess.

Alain de Botton is a philosopher, author, and founder of The School of Life. How can we truly understand ourselves? Most of us either ignore our emotions or overthink them, turning simple feelings into complex puzzles. So how do we navigate the minefield of emotion to grow and become better? Sponsors: See discounts for all the products I use and recommend: https://chriswillx.com/deals Get a Free Sample Pack of LMNT’s most popular flavours with your first purchase at https://drinklmnt.com/modernwisdom Get 35% off your first subscription on the best supplements from Momentous at https://livemomentous.com/modernwisdom Get Free Travel Packs, Free Liquid Vitamin D, and more from AG1 at https://ag1.info/modernwisdom Get $100 off the best bloodwork analysis in America at https://functionhealth.com/modernwisdom Extra Stuff: Main website: https://www.theschooloflife.com/ Newsletter sign up: https://www.theschooloflife.com/signup/ Shop: https://shop.theschooloflife.com/ Get my free reading list of 100 books to read before you die: https://chriswillx.com/books Try my productivity energy drink Neutonic: https://neutonic.com/modernwisdom Episodes You Might Enjoy: #577 - David Goggins - This Is How To Master Your Life: https://tinyurl.com/43hv6y59 #712 - Dr Jordan Peterson - How To Destroy Your Negative Beliefs: https://tinyurl.com/2rtz7avf #700 - Dr Andrew Huberman - The Secret Tools To Hack Your Brain: https://tinyurl.com/3ccn5vkp - Get In Touch: Instagram: https://www.instagram.com/chriswillx Twitter: https://www.twitter.com/chriswillx YouTube: https://www.youtube.com/modernwisdompodcast Email: https://chriswillx.com/contact - Learn more about your ad choices. Visit megaphone.fm/adchoices

America loves winners—now more than ever. But how do you get to a win in 2025 America? We watch someone trying to score a win in a game whose rules are being made up as she plays.  Visit thisamericanlife.org/lifepartners to sign up for our premium subscription.Prologue: Ira talks to producer Diane Wu about an informal survey she’s done with the staff of This American Life about a phrase Ira says a lot that includes the word “winners.” (8 minutes)Act One: Two people see one of President Trump’s first executive orders and get excited, and then get to work. (46 minutes)Transcripts are available at thisamericanlife.orgThis American Life privacy policy.Learn more about sponsor message choices.